Rat CTR&RAMP1 CRE-Luc CHO
CBP71657
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| I. Background | |
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大鼠CTR（降钙素受体）与RAMP1（受体活性修饰蛋白1）共同组成AMY1型胰淀素受体（AMY1），这是CGRP（降钙素基因相关肽）和胰淀素的功能性高亲和力受体复合物。在三叉神经节等组织中，CTR与RAMP1存在共表达，介导CGRP相关信号传导。与CLR/RAMP1组成的经典CGRP受体不同，CTR/RAMP1复合物也能被大鼠胰淀素（rAmy）有效激活，构成功能交叉的受体系统。 |
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| II. Description | |
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Rat CTR&RAMP1 CRE-Luc CHO 药靶模型很好的模拟了体内 Rat CTR&RAMP1 的信号转导过程。 |
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| III. Introduction | |
| Expressed gene: | Rat CTR&RAMP1 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K + 10%FBS + 5μg/ml Puromycin + 5μg/ml Blasticidin + 600μg/ml Hygromycin B |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional assay for Rat CTR&RAMP1 |
| Transducer: | Gs |
IV. Representative Data Figure 1. Dose Response of Agonists in Rat CTR&RAMP1 CRE-Luc CHO(C36) .  Figure 2. HTRF cAMP Assay with Rat CTR&RAMP1 CRE-Luc CHO(C36) . |
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